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A Call to Action: Intensive Lifestyle Intervention Against Diabesity |Debridement of necrotic, callus, fibrous, and senescent tissues is a mainstay of ulcer therapy. 42,43 It is considered the first and the most important therapeutic step leading to wound closure in patients with DFU. 42-44 Unhealthy tissue must be sharply debrided back to bleeding tissue to fully visualize the extent of the ...